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. Author manuscript; available in PMC: 2016 Feb 24.
Published in final edited form as: Semin Cell Dev Biol. 2014 Sep 16;37:98–107. doi: 10.1016/j.semcdb.2014.09.007

Fig. 4.

Fig. 4

Synaptic type IIa RPTP-ligand complexes. (a) Cartoon illustrating the trans interaction mode observed in the chicken RPTPσ Ig12:TrkC LRRIg1 crystal structure (PDB accession code 4PBW) [57]. The three major binding sites are indicated by arrows and white labels. Protein features labelled as follows: Ig, immunoglobulin-like domain; LRR, leucine rich repeat domain (containing NT, amino-terminal cap; 1–3, leucine rich repeats; CT, carboxy-terminal cap); N, amino-terminus; C, carboxy-terminus; black arrowheads, potential meA and meB insertions; orange loop, RPTPσ Lys-loop. (b) Cartoon to illustrate the overlap of the sucrose octasulphate binding site on LAR (based on PDB accession code 2YD8 [58]) with the RPTPσ:TrkC interface. HS and heparin oligosaccharides have been shown to compete with TrkC for RPTPσ binding [57].