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. 2016 Feb 24;5:35. doi: 10.1186/s13643-016-0210-z

Table 3.

Summary of results from the literature: risk factors, relevance of studies and main results

Factors n studies n studies with significant results Relevance Results
High (low risk of bias) Moderate (unclear risk of bias) Low (high risk of bias)
Socio-demographic
 Age 19 12 4 4 4 Women aged ≥50 and men aged ≥55 are more at risk.
 Education or income 15 9 3 3 3 Low educational and income levels predict prolonged time to RTW.
Disease and treatment-related
 Cancer site 13 11 3 4 4 Head and neck, lung and breast cancers and leukaemia impede RTW.
 Stage 7 6 1 3 2 Advanced cancer stages substantially lengthen sickness leave.
 Treatment 21 18 1 9 8 Chemotherapy and combination of therapies are negatively associated with RTW.
 Symptoms 11 11 0 6 5 Fatigue, pain and depression are the main impeding symptoms.
Work-related
 Type, sector and job demands 13 12 4 4 4 Lower occupational class, private sector and demanding jobs impede the (time to) RTW.
 Employers’ and colleagues’ support 7 7 0 0 7 Support of colleagues and employers predict quicker and easier RTW.
Personal and subjective
 Value of work 7 7 1 1 5 The (re)evaluation of the importance of paid work substantially affects the choice to RTW.
Total 43 10 19 14