Table 4.

Treatment-related toxicity profiles

	Afatinib		Erlotinib		p-value
	All grades (%)	≥Grade 3 (%)	All grades (%)	≥Grade 3 (%)	All grades	≥Grade 3
Rash	15 (60.0)	0 (0.0)	19 (67.9)	5 (17.9)	0.04	0.03
Diarrhea	15 (60.0)	7 (28.0)	3 (10.7)	1 (3.6)	0.002	0.01
Mucositis	1 (4.0)	0 (0.0)	0 (0.0)	0 (0.0)	0.29	NA
Paronychia	2 (8.0)	0 (0.0)	0 (0.0)	0 (0.0)	0.31	NA
Impaired liver function	6 (24.0)	0 (0.0)	1 (3.6)	0 (0.0)	0.02	NA
Hypokalemia	2 (8.0)	2 (8.0)	0 (0.0)	0 (0.0)	0.13	0.13

Abbreviation: NA not applicable