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. 2016 Feb 24;15:37. doi: 10.1186/s12944-016-0208-5

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© Han et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mechanism of (−)-HCA effect on hepatic lipids metabolism. Supplemental (−)-HCA inhibited lipogenesis by inhibiting ACLY, SREBP-1c and FAS expression, and accelerated lipolysis through enhancing HL activity and PPARα expression, which eventually led to reduced abdominal fat deposition in broiler chickens. The variance of gene expression which involved in lipid metabolism might associate with the mechanism of how (−)-HCA reduced the accumulation of fat in broiler chickens