Table 1.
Numbers of non-synonymous mutations in Plasmodium falciparum K13 gene corresponding to amino acids 210–726 in different sites in Myanmar
| Ann | Homemalin | Myit Kyi Nar | Kyauk Me | Phruso | Total | |
|---|---|---|---|---|---|---|
| Total n | 64 | 91 | 32 | 13 | 6 | 206 |
| Wild type | 61** | 59** | 6 | 0 | 4 | 126 |
| Non-propeller mutations | ||||||
| R254L* | 1 | 1 | ||||
| R255K | 2 | 2 | ||||
| E294G* | 1 | 1 | ||||
| I352T | 2 | 2 | ||||
| R411K* | 1 | 1 | ||||
| Total | 0 | 6 | 1 | 0 | 0 | 7 |
| % | 0 | 6.6 | 3.2 | 0 | 0 | 3.4 |
| (95 % CI) | (0.0–5.7) | (3.0–13.6) | (0.56–15.8) | (0–22.8) | (0–39.0) | (1.7–6.8) |
| Propeller mutations | ||||||
| P441L | 1 | 1 | ||||
| P443S | 3 | 3 | ||||
| F446I | 13 | 18 | 1 | 32 | ||
| G449A | 1 | 1 | 2 | |||
| S485N | 1 | 1 | ||||
| Y511H* | 1 | 1 | ||||
| A529T* | 1 | 1 | ||||
| N554L* | 1 | 1 | ||||
| P574L | 1 | 2 | 12 | 15 | ||
| R561H | 1 | 1 | ||||
| R575K | 1 | 1 | ||||
| A675V | 2 | 2 | ||||
| A676D | 4 | 3 | 7 | |||
| H719N | 1 | 1 | ||||
| Total | 3 | 26 | 25 | 13 | 2 | 69 |
| % | 4.7 | 28.6 | 78.1 | 100 | 33.3 | 33.5 |
| (95 % CI) | (1.6–12.9) | (20.3–38.6) | (61.2–89.0) | (77.2–100) | (9.7–70.0) | (27.4–40.2) |
* Newly identified mutations from this study
** Includes single samples with previously unreported synonymous mutations in Ann (E424E) and Homemalin (D343D)