Table 2.

Module assignments for FTD-genes in frontal and temporal cortex

FTD genes	Affymetrix ID	type	Frontal cortex				Temporal cortex
			module	Sz (n)	MM	1-q	module	Sz (n)	MM	1-q
MAPT	3723687	pure	black	791	0.83	0.03	lightyellow	210	0.67	0.31
GRN	3722917				0.66	0.34	cyan	276	0.56	0.51
CHMP2B	2631845		darkolivegreen	63	0.76	0.48	green	1439	0.53	0.49
HLA-DRA	2903189		darkred ( p  = 0.0046)	141	0.8	0.23	lightcyan ( p  = 0.0139)	250	0.66	0.51
CTSC	3385769				0.73	0.5			0.69	0.47
TMEM106B	2990342		red	925	0.78	0.04	darkturquoise	164	0.86	0.01
C9orf72	3202421	spectrum	purple ( p  = 0.0226)	1559	0.74	0.1	purple ( p  = 0.0206)	830	0.75	0.14
VCP	3204404				0.68	0.19			0.71	0.24
UBQLN2	3978999				0.55	0.45			0.63	0.45
OPTN	3235726				0.59	0.38	grey60	220	0.53	0.8
FUS	3656904		lightcyan	209	0.58	0.61	midnightblue	268	0.64	0.31
FUS	3656950		blue	3329	0.31	0.69	pink	2979	0.39	0.58
FUS	3656954				0.5	0.38	magenta	1000	0.44	0.72
TDP-43	2320048		turquoise	4759	0.22	0.89			0.53	0.54

The FTD-genes (with corresponding Affymetrix IDs) are listed. Co-expression modules for the FTD-genes and their relevance within modules are displayed. Sz = size, i.e. number of transcripts contained in the module; MM = module membership; 1-q = 1-quantile of MM. The bolded parts highlight the fact that WGCNA indicated the following: 1) (MAPT and GRN), (HLA-DRA and CTSC), (C9orf72, VCP, UBQLN2 and OPTN) and (2 FUS) transcripts were respectively present in the same modules in frontal cortex, and; 2) (HLA-DRA and CTSC), (C9orf72, VCP and UBQLN2) and (FUS and TARDBP) transcripts were respectively present in the same modules in temporal cortex. The modules containing (HLA-DRA and CTSC) and (C9orf72, VCP, UBQLN2 [and OPTN]) were significantly enriched for FTD transcripts