Table 2.

Autoantigens recognized in NOD mice by autoreactive T cells

AUTOANTIGEN	AA* Position	MHC RESTRICTION	CLONE	CAPABLE OF INDUCING DIABETES?	REFERENCES
Insulin	A14–20	H-2Db	AI4	YES	[47]
	B9–23	I-Ag7	2H6	NO (protective)	[48]
	B9–23	I-Ag7	BDC12-4.1	YES	[49]
	B9–23	I-Ag7	BDC12-4.4	YES	[49, 50]
	B12–25	I-Ag7	2H6	NO (protective)	[48]
	B15–23	H-2Kd	G9C8	YES (if activated or with CD4 T cell help)	[51, 52]
	B15–23	H-2Kd	A1**	YES	[53]
IGRP	206–214	H-2Kd	NY8.3	YES (if activated)	[38, 54]
CHROMOGRANIN A	359–372	I-Ag7	BDC2.5	YES	[55]
	359–372	I-Ag7	BDC10.1	YES	[55, 56]
GAD65	286–300	I-Ag7	B16.3	NO (protective)	[57]
	515–524	H-2Kd	R1**	NO (delayed diabetes when transferred intra-peritoneally into neonatal NOD mice)	[58]
GAD67	515–524	H-2Kd	C2**	UNKNOWN	[59]
Hsp60	437–460	I-Ag7	C9	YES (if activated)	[60, 61]
ZnT8	345–359	I-Ag7	10.8**	YES (if recipient lightly irradiated)	[62]

^*Amino acid (AA)

^**Peptide induced responses