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. 2016 Jan 27;75(2):102–110. doi: 10.1093/jnen/nlv020

FIGURE 3.

FIGURE 3

Pathological findings in human and zebrafish X-linked myotubular myopathy (XLMTM). (A) Hematoxylin and eosin (H&E)-stained longitudinal myofibers from myotubular myopathy (MTM) and age-matched control (CTL) human muscle biopsies. Arrows indicate abnormal nuclei. (B) H&E-stained longitudinal myofibers from zebrafish control (CTL MO) and myotubularin morphant (MTM MO) 72-hour-postfertilization embryos. Myonuclei are abnormally rounded (arrows), and there is increased space between fibers in the morphant (*). (C) Toluidine blue-stained semi-thin sections from 72-hour-postfertilization morphants. Myonuclei from myotubularin morphants are large, abnormally rounded, and contain discrete nucleoli (arrows). Sarcomeric units are normal in appearance. Scale bar = 20 µm. Reproduced with permission from Dowling JJ, Vreede AP, Low SE et al. Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy. PLoS Genet 2009;5:e100372. Copyright © 2009 Dowling et al.