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. Author manuscript; available in PMC: 2016 Feb 24.

Published in final edited form as: Curr Top Med Chem. 2009;9(13):1217–1226. doi: 10.2174/156802609789753635

Table 1.

Potency and selectivity of analogs 18 of the HTS lead 7.



Cmpd	R	M1 IC₅₀ (μM)^a	M2 IC₅₀ (μM)^a	M3 IC₅₀ (μM)^a	M4 IC₅₀ (μM)^a	M5 IC₅₀ (μM)^a
7		13.2	>150	>150	>150	>150
18a		>150	>150	>150	>150	>150
18b		4.6	>150	>150	>150	>150
18c		5.0	>150	>150	66	>150
18d		5.6	>150	>150	>150	>150
18e		1.15	29	24	20	13
18f		1.1	52	70	18	7.6
18g		3.3	>150	>150	>150	>150
18h		18.8	>150	>150	>150	>150
18i		0.44	3.5	3.1	>150	1.1

^a

IC₅₀s are an average of three independent experiments using rat mAChR (CHO) cell lines.