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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Cell Rep. 2016 Jan 14;14(4):795–807. doi: 10.1016/j.celrep.2015.12.068

Figure 1. Sensory adaptation modulates burst/tonic firing.

Figure 1

A. Extracellular recordings from the ventral posteromedial (VPm) nucleus of the thalamus during sensory stimulation and, in a subset of animals transfected with channelrhodopsin, light modulation applied via an optic fiber. Waveform scale bars: 200μV, 200 μs. B. Example neural response to a sensory feature (AF = 8°) presented in isolation (AN = 0°) and with adaptation (AN = 0.168°, 125°/s) with burst spikes colored red and tonic spikes colored gray. AF: Amplitude of stick-slip feature (°); AN: Standard deviation of adapting noise (°); RF: Feature-evoked response; RN: Adapting noise-evoked response. Scale bars: 4°, 250 ms, 100 Hz. C. Mean evoked response to Not Adapted features responses (black; AN = 0°) and Adapted feature responses (grey; AN :0.168°) across cells (n = 26 cells; mean ± SEM, *p<0.05, paired Wilcoxon signed-rank test with Bonferroni-Holm correction). D. First spike latency jitter in response to Adapted features (grey) and Not Adapted features (black) (n = 26 cells; mean ± SEM, *p<0.05, paired Wilcoxon signed-rank test with Bonferroni-Holm correction). E. A burst is defined as two or more spikes with an interspike interval of four milliseconds or less (tisi) with the first spike preceded by at least 100 milliseconds of silence (tinhib). F. Example neuron recording from the awake behaving animal in response to sensory features with and without noise (AF = 9°, AN = 0.48°). Scale bars: 4°, 100 Hz, 250 ms. G. Feature burst ratio in Adapted and Not Adapted condition across cells (n = 33 cells (26 cells from anesthetized preparation, black; 7 cells from awake preparation, green), p = 4.99e-6, paired Wilcoxon signed-rank test).