Table 2.
Genotype distributions, minor allele frequencies, and unadjusted p-values for comparing genotype distributions according to diabetes and BMI status
| No diabetes | Diabetes | p-value | Normal weight |
overweight | Obese | p-value | Overall | |
| N | 328 | 152 | 118 | 129 | 233 | 532 | ||
| ENPP1-rs997509 | ||||||||
| C/C, n (%) | 254 (77.4) | 121 (79.6) | 0.186 | 97 (82.2) |
94 (72.9) | 184 (79.0) |
0.342 | 375 (78.1) |
| C/T, n (%) | 70 (21.3) | 26 (17.1) | 28 (15.2) |
33 (25.6) | 45 (19.3) |
96 (20.0) |
||
| T/T, n (%) | 4 (1.2) | 5 (3.3) | 3 (2.5) | 2 (1.5) | 4 (1.7) | 9 (1.9) | ||
| T, n (%) | 78 (11.9) | 36 (11.8) | 0.920 | 34 (14.4) |
37 (14.3) | 53 (11.4) |
0.383 | 114 (11.9) |
| HWE (p-value) | >0.999 | 0.038 | 0.095 | >0.999 | 0.511 | 0.379 | ||
| ENPP1-rs1044498 | ||||||||
| C/C, n (%) | 81 (24.7) | 41 (27.0) | 0.548 | 33 (28.0) |
35 (25.6) | 56 (24.0) |
0.852 | 122 (25.0) |
| C/A, n (%) | 175 (53.4) | 73 (48.0) | 62 (52.5) |
66 (51.2) | 120 (51.5) |
248 (51.7) |
||
| A/A, n (%) | 72 (21.9) | 38 (25.0) | 23 (19.5) |
30 (23.3) | 57 (24.5) |
110 (22.9) |
||
| A, n (%) | 319 (48.6) | 149 (49.0) | >0.999 | 108 (45.8) |
126 (48.8) | 234 (50.2) |
0.538 | 468 (48.8) |
| HWE (p-value) | 0.269 | 0.629 | 0.582 | 0.861 | 0.695 | 0.522 | ||
| FTO-9941349 | ||||||||
| C/C, n (%) | 187 (57.0) | 73 (48.0) | 0.185 | 63 (53.4) |
64 (49.6) | 133 (57.1) |
0.595 | 260 (54.2) |
| C/T, n (%) | 118 (36.0) | 66 (43.4) | 44 (37.3) |
56 (43.4) | 84 (36.0) |
184 (38.3) |
||
| T/T, n (%) | 23 (7.0) | 13 (8.5) | 11 (9.3) | 9 (7.0) | 16 (6.9) |
36 (7.5) | ||
| T, n (%) | 164 (25.0) | 92 (30.3) | 0.102 | 66 (28.0) |
74 (28.7) | 116 (24.9) |
0.475 | 256 (26.7) |
| HWE (p-value) | 0.463 | 0.848 | 0.492 | 0.666 | 0.599 | 0.642 | ||
| FTO-rs3751812 | ||||||||
| G/G, n (%) | 218 (66.5) | 93 (61.2) | 0.516 | 75 (63.6) |
79 (61.2) | 157 (67.4) |
0.761 | 311 (64.8) |
| G/T, n (%) | 100 (30.5) | 53 (34.9) | 38 (32.2) |
46 (35.7) | 69 (29.6) |
153 (31.9) |
||
| T/T, n (%) | 10 (3.0) | 6 (3.9) | 5 (4.2) | 4 (3.1) | 7 (3.0) | 16 (3.3) | ||
| T, n (%) | 120 (18.3) | 65 (21.4) | 0.299 | 48 (20.3) |
54 (20.9) | 83 (17.8) |
0.530 | 185 (19.3) |
| HWE (p-value) | 0.854 | 0.810 | >0.999 | 0.593 | >0.999 | 0.662 | ||
| TCF7L2-rs12255372 | ||||||||
| G/G, n (%) | 221 (67.4) | 92 (60.5) | 0.305 | 72 (61.0) |
88 (68.2) | 153 (65.7) |
0.623 | 313 (65.2) |
| G/T, n (%) | 92 (28.0) | 50 (32.9) | 37 (31.6) |
36 (27.9) | 69 (29.6) |
142 (29.6) |
||
| T/T, n (%) | 15 (4.6) | 10 (6.6) | 9 (7.6) | 5 (3.9) | 11 (4.7) |
25 (5.2) | ||
| T, n (%) | 122 (18.6) | 70 (23.0) | 0.131 | 55 (23.3) |
46 (17.8) | 91 (19.5) |
0.295 | 192 (20.0) |
| HWE (p-value) | 0.200 | 0.364 | 0.197 | 0.552 | 0.403 | 0.115 | ||
| TCF7L2-rs7903146 | ||||||||
| C/C, n (%) | 184 (56.1) | 66 (43.4) | 0.025 | 57 (48.3) |
66 (51.2) | 127 (54.5) |
0.330 | 250 (52.1) |
| C/T, n (%) | 129 (39.3) | 74 (48.7) | 52 (44.0) |
53 (41.1) | 98 (42.1) |
203 (42.3) |
||
| T/T, n (%) | 15 (4.6) | 12 (7.9) | 9 (7.6) | 10 (7.7) | 8 (3.4) | 27 (5.6) | ||
| T, n (%) | 159 (24.2) | 98 (32.2) | 0.011 | 70 (29.7) |
73 (28.3) | 114 (24.5) |
0.275 | 257 (26.8) |
| HWE (p-value) | 0.231 | 0.196 | 0.661 | >0.999 | 0.050 | 0.103 |
Abbreviation: ENPP1, ectonucleotide pyrophosphatase/phosphodiesterase gene; FTO, fat mass and obesity-associated gene; TCF7L2, transcription factor 7-like 2 gene; HWE, Hardy-Weindberg Equilibrium (HWE p-values are from exact tests)