Table 2.
Evaluation of in vitro antiplasmodial activity of the different compounds tested on P. falciparum F32 and FcM29 strains in comparison with chloroquine as reference (IC50 in µg/mL)
| Compounds | F32/24h | F32/72h | FcM29/24h | FcM29/72H | |
| IC50 | IC50 | IC50 | IC50 | ||
| 1,7-dihydroxy xanthone | 1 | 16.05 +/− 9.02 | 19.87 +/− 19.15 | 17.93 +/− 5.40 | 15.34 +/− 4.23 |
| macluraxanthone | 4 | 0.46 +/− 0.12 | 0.36 +/− 0.06 | 0.33 +/− 0.08 | 0.27 +/− 0.01 |
| allaxanthone B | 8 | 3.70 +/− 1.05 | 3.09 +/− 0.13 | 3.93 +/− 0.40 | 3.43 +/− 0.57 |
| morreloflavone | 9 | 11.77 +/− 9.55 | 3.36 +/− 2.00 | 12.59 +/− 12.03 | 4.80 +/− 2.21 |
| volkensiflavone | 10 | 0.99 +/− 0.62 | 1.18 +/− 1.25 | 0.93 +/− 0.20 | 0.95 +/− 0.27 |
| morreloflavone 7-O-glucoside | 11 | 11.45 +/− 14.51 | 8.38 +/− 10.87 | 28.92 +/− 7.45 | 23.82 +/− 7.58 |
| chloroquine | 0.036 | 0.036 | 0.57 | 0.57 | |
| EAF | 5.38 +/− 0.83 | 5.43 +/− 1.31 | 4.92 +/− 1.43 | 4.48 +/− 1.47 | |
| EAG | 35.38 +/− 2.87 | 32.01 +/− 1.21 | 25.17 +/− 2.87 | 24.30 +/− 4.04 | |
| EAM | 3.27 +/− 0.25 | 3.33 +/− 0.17 | 3.08 +/− 0.08 | 2.13 +/− 1.07 | |
EAF: Crude extract of the bark of A. floribunda, EAM: Crude extract from the bark of A. monticola, EAG: Crude extract fromthe bark of A. gabonensis.