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Schematic on the role of Mhrts long noncoding RNAs in cardiac hypertrophy. In the basal condition, the locus of Myh7 encodes a cluster of lncRNAs known as Mhrts (myosin heavy-chain-associated RNA transcripts), which repress the transcription of Myh7. In response to a hypertrophic stimulus, the Brg1-HDAC-Parp chromatin repressor complex inhibits the transcription of Mhrts, causing transcription activation of Myh7.
