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. 2015 Dec;16(6):393–404. doi: 10.2174/1389202916666150817203144

Fig. (2).

Fig. (2)

miRNAs and cartilage degenerating enzymes (MMP1, MMP3, MMP13 and ADAMTS). miR-9, 22, 27b, 181, 488 suppress cartilage matrix catabolism mainly by their effect on MMP13. miR-320 and 142-3p target ADAMTS; miR-203, miR-155, and miR-18a suppress the activation of MMP1. miR-146a, 140, 125, 148a, 602, 608 can regulate cartilage matrix homeostasis by acting on MMP13 and ADAMTS. Similarly, miR-24, 558, 127, 1 can suppress both MMP1 and MMP3. In addition, miR-21 increases the expression of MMP1 and MMP3.