Table 3.

In vivo study using miRNA for bone regeneration.

	Disease	Model	microRNA	Administration Method	Animal	Reference
1	Osteoporosis	Ovariectomy	antimir-214	Systemic injection	Mouse	[80]
2	Fracture	Femoral fracture	antimir-92a	Systemic or local injection	Mouse	[88]
3	Bone defect	8mm diameter bony defect on calvarium	BMSC transfected antimir-31 on poly glycerol sebacute scafffold	Implantation	Rat	[89]
4	Bone defect	5mm diameter bony defect on calvarium	ADSC transfected with antimir-31 on β-TCP	Implantation	Rat	[90]
5	Bone defect	5mm diameter bony defect on calvarium	MSC transfected with antimir-26a on hydrogel	Implantation	Mouse	[91]
6	Normal	Subcutanous	Freeze dried allograft bone wraped with BMSC sheet transfected with antimir-138	Implantation	Mouse	[93]
7	Bone defect	10mm diameter orbital wall bony defect	BMSC transfected with antimir-31 on β-TCP	Implantation	Canin	[94]
8	Bone defect	4mm diameter bony defect on calvarium	ADSC transfected with photoactivated miR-148b mimic -SNP conjugate on polycaprolactom	Implantation	Mouse	[95]