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Cumulative fraction of enzymes whose active sites match pocket residues in ( A) other classes of enzymes in native structures with different first two digit Enzyme Commission (EC) numbers, ( B) in non-enzymes, and ( C) in ART structures. For each target enzyme, we count the number of alternative enzyme classes that contain at least a hit by the target enzyme at various root-mean-square-deviation (RMSD) cut-offs.
