Figure 2. Deriving the predicted values used by Crambled.
Top left: The basic predicted depths of sequencing and allele fractions that are expected for a number of copy number states. Top right: For six cases the uncertainty in the allele fraction that will be observed is illustrated. Bottom left: When the distribution folds at the 0.5 level, the expected value of the allele fraction is reduced. Bottom right: The predicted depths of sequencing and allele fractions that are used in the Crambled tool.
