African elephant skin nodules. Typical herpesvirus skin nodules observed on the trunk and head of 1% of healthy juvenile African elephants in Africa, as well as in the outbreak among a large group of young orphan African calves imported from Zimbabwe to Florida (Jacobson et al. 1986). Similar skin nodules biopsied from Kenyan elephants have been found to contain DNA from multiple viruses, including EEHV2, EEHV3, EEHV7, several types of elephant gammaherpesviruses (EGHVs), and African elephant polyomavirus (V.R. Pearson, personal communication, 2013. Fox Chase Cancer center, Philadelphia; Finding EEHVs in Wild African Elephants by Virginia Pearson https://elephantmanagers.com/…/ElephantManagersArticleKWS__1_.doc. August 2012). (A) Photograph of regressed skin nodules from the trunk of an African elephant. (B) Photograph of a proliferative skin nodule from the trunk of an African elephant. Reproduced with permission from Elliot Jacobson and Journal of the American Veterinary Medical Association.