Table 1. Summary of in vitro network and behavioural observations at different stages of the RISE model.

Time point	Network activity	Behaviour/PSBB
control	Gamma band	Normal/no aggression
24h post status	Theta, gamma and HFO	Oro-facial twitches; forelimb clonus; no aggression or aversion
Latent period	Low power gamma	Normal; some animals showing aggression on handling
SRS	High power gamma	Recurrent seizures; aggression on handling; backing away from foreign objetcs