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Gene expression patterns of Six1 and P53 gene in MCF-7 and MCF-7/Pac 64 nM cells. Ribosomal β-actin was used as housekeeping gene. Effects of paclitaxel on pro/anti-apoptotic genes: (a) Level of mRNA of Six1 was increased significantly in MCF-7/Pac 64 nM (p = 0.0007) compared with MCF-7 cell line, (b) Level of p53 did not change significantly in paclitaxel-resistant cell line compare with parent MCF-7 cell line MCF-7/Pac 64 nM.
