Table 2.
Cerebrospinal fluid monoamine metabolites and their correlations compared by EEG classification.
| EEG Data | MHPG (nM) | 5-HIAA (nM) | HVA (nM) | Pearson correlation, r | ||
|---|---|---|---|---|---|---|
| MHPG vs. 5-HIAA | MHPG vs. HVA | 5-HIAA vs. HVA | ||||
| IED ± (N=128, F 71%) | 85.6 ± 21.1 | 228.7 ± 94.5 | 564.8 ± 166.3 | 0.281*** | 0.346*** | 0.649*** |
| IED− (N=135, F 78%) | 87.9 ± 20.5 | 230.1 ± 92.8 | 565.0 ± 194.4 | 0.277*** | 0.368*** | 0.644*** |
| PS ± (N=66, F 62%) | 84.7 ± 19.2 | 223 ± 107.4 | 557.9 ± 173.2 | 0.410*** | 0.471*** | 0.766*** |
| PS− (N=197, F 79%) | 87.5 ± 21.3 | 231.5 ± 88.5 | 567.2 ± 183.8 | 0.233*** | 0.323*** | 0.602*** |
The concentrations of metabolites (MHPG, 5-HIAA and HVA in nM, i.e., pmol/mL) were compared between baboons with (IED ±) and without (IED−) interictal epileptic discharges or with (PS ±) or without (PS−) photoepileptic responses (PS) on scalp EEG using a one-way ANOVA with post-hoc Tukey’s multiple comparison tests for each metabolite (left three data columns). F, Females. The results are presented as mean ±/− S.D. The Pearson (r) correlation analyses of CSF metabolite concentrations are shown in the right three data columns. Bold values indicate significant differences (*p<0.05). The alpha level was set at 0.05:
p<0.05;
p<0.01;
p<0.001.