Table 1.

Meta-Analysis Summary for Subgroups Analyses of Crude Relative Risk of Stroke in Patients with MRI defined Silent Brain Infarct

						Test of Heterogeneity	Publication bias
Subgroup	No. of Studies	Total person-years of follow-up	SBI Prevalence	Pooled RR (95% CI)	RR P-value	Cochran’s Q P-value	Kendall’s τ	P-value
Stroke-free individuals recruited from population-based or community-dwelling samples15, 18, 19, 23, 25, 28	6	95,449.2	17.7%	2.81 (2.40–3.28)	<0.01	<0.01	0.07	0.99
Stroke-free individuals with at least 1 known stroke risk factor16, 17, 21, 26	4	5,813.4	38.1%	4.54 (2.76–7.45)	<0.01	0.50	0.33	0.75
Known history of stroke followed for stroke recurrence20, 22, 24	3	7097.6	27.5%	1.99 (1.30–3.04)	<0.01	0.21

^*Publication bias test only performed on greater than 3 studies

CI indicates confidence interval; RR, relative risk