Table 3. Risk of Ischemic Stroke or Central Nervous System Hemorrhage Unadjusted and Adjusted by Potential Confounders.
| Model 1* | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95%) | p | HR (95%) | p | HR (95%) | p | HR (95%) | ||
| IL6 continuous (per SD=11.98) | 1.1 (1.0, 1.2) | 0.010 | 1.1 (1.0, 1.2) | 0.002 | 1.1 (1.0, 1.2) | 0.006 | 1.1 (1.0, 1.2) | 0.014 |
| IL6 | 0.28 | 0.28 | 0.38 | 0.40 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.70 [0.37,1.34] | 0.71[0.37,1.36] | 0.73[0.38,1.41] | 0.74[0.38,1.43] | ||||
| Quartile 3 | 1.29 [0.74,2.26] | 1.31[0.74,2.31] | 1.27[0.71,2.28] | 1.27 [0.71,2.29] | ||||
| Quartile 4 | 1.01[0.56,1.83] | 1.07[0.59,1.94] | 1.08[0.58,2.01] | 1.11[0.60,2.06] | ||||
| MCP1 continuous (per SD=127.93) | 1.1 (0.87, 1.4) | 0.47 | 1.1 (0.89, 1.4) | 0.34 | 1.1 (0.83, 1.4) | 0.27 | 1.1 (0.85, 1.4) | 0.52 |
| MCP1 | 0.37 | 0.42 | 0.52 | 0.45 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.60[0.29,1.25] | 0.61[0.29,1.32] | 0.64[0.30,1.39] | 0.65[0.30,1.42] | ||||
| Quartile 3 | 0.81 [0.41,1.58] | 0.82 [0.40,1.68] | 0.78[0.38,1.64] | 0.84[0.40,1.77] | ||||
| Quartile 4 | 1.11[0.60,2.07] | 1.12[0.58,2.18] | 1.07[0.55,2.12] | 1.18[0.59,2.33] | ||||
| SAA continuous (per SD=22.6) | 1.1 (0.93 1.2) | 0.39 | 1.1 (0.94, 1.2) | 0.34 | 1.1 (0.93, 1.2) | 0.34 | 1.1 (0.95, 1.2) | 0.25 |
| SAA | 0.56 | 0.50 | 0.43 | 0.39 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.71[0.39,1.29] | 0.71[0.39,1.31] | 0.68[0.37,1.26] | 0.67[0.36,1.25] | ||||
| Quartile 3 | 0.75 [0.42,1.36] | 0.76[0.42,1.38] | 0.74[0.40,1.36] | 0.72[0.39,1.34] | ||||
| Quartile 4 | 0.98[0.57,1.70] | 1.05[0.60,1.84] | 1.04[0.59,1.85] | 1.04[0.59,1.85] | ||||
| TNFR1 continuous (per SD=1.46) | 1.2 (1.0, 1.4) | 0.049 | 1.2 (0.99, 1.4) | 0.054 | 1.1 (0.94, 1.3) | 0.21 | 1.1 (0.95, 1.4) | 0.15 |
| TNFR1 | 0.17 | 0.19 | 0.37 | 0.30 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.92[0.46,1.81] | 0.90[0.45,1.78] | 0.83[0.41,1.66] | 0.83[0.41,1.67] | ||||
| Quartile 3 | 1.51 [0.82,2.76] | 1.45[0.79,2.67] | 1.37[0.74,2.54] | 1.43[0.77,2.66] | ||||
| Quartile 4 | 1.61[0.88,2.95] | 1.62[0.87,3.00] | 1.33[0.71,2.50] | 1.36[0.72,2.56] | ||||
| CD40L continuous (per SD=4.39) | 0.99 (0.80, 1.2) | 0.89 | 1.0 (0.83,1.3) | 0.73 | 0.99 (0.78, 1.3) | 0.92 | 0.98 (0.77, 1.2) | 0.86 |
| CD40L | 0.80 | 0.93 | 0.82 | 0.81 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 1.03[0.58,1.80] | 1.00[0.57,1.76] | 1.10[0.62,1.94] | 1.09[0.61,1.93] | ||||
| Quartile 3 | 0.81 [0.45,1.47] | 0.84[0.46,1.54] | 0.87[0.48,1.60] | 0.91[0.49,1.67] | ||||
| Quartile 4 | 0.82[0.45,1.50] | 0.91[0.49,1.70] | 0.83[0.43,1.59] | 0.80[0.42,1.53] | ||||
- Unadjusted
- Adjusted for Demographics (Age, Sex, Race, Region)
- Adjusted for Demographics (Age, Sex, Race, Region) and Co-morbidities (Hypertension, Smoking, History of Prior Ischemic Stroke, Diabetes, LDL and HDL)
- Adjusted for Demographics (Age, Sex, Race, Region) Co-morbidities (Hypertension, Smoking, History of Prior Ischemic Stroke, Diabetes, Low Density Lipoprotein and High Density Lipoprotein) and Statin use at baseline