Table 4. Genes involved in LTD pathway.
The LTD pathway was found to be overrepresented in the genes pinpointed by our joint LD and linkage analysis of composing.
| Region | p-value | SNP | Gene | Part of molecule or cascade in LTD pathway |
|---|---|---|---|---|
| 1p36 | 7.0x10-6 | rs11799849 | PLA2G5 | PLA2 |
| PLA2G2A | PLA2 | |||
| PLA2G2C | PLA2 | |||
| PLA2G2D | PLA2 | |||
| PLA2G2E | PLA2 | |||
| PLA2G2F | PLA2 | |||
| 1p13.2 | 3.6x10-5 | rs10801911 | NRAS | RAS: RAS/RAF/MAP kinase cascade |
| 1p13.1 | 9.6x10-5 | rs639208 | PPM1J | PP2A |
| 2p21 | 2.7x10-5 | rs4233921 | PRKD3 | PKC |
| 3p26.1 | 7.2x10-5 | rs163968 | GRM7 | mGluR |
| 4q22 | 1.4x10-5 | rs1905724 | GRID2 | GRID |
| 9q34 | 6.4x10-5 | rs11793700 | PPP2R4 | PP2A |
| 10p15 | 7.0x10-5 | rs12357847 | PRKCQ | PKC |
| 11p15.2 | 6.6x10-5 | rs10766117 | RRAS2 | RAS: RAS/RAF/MAP kinase cascade |
| 15q26.3 | 6.2x10-5 | rs1223954 | IGF1R | IGF1R |
| 17q21.31 | 8.6x10-5 | rs3744760 | CRHR1 | CRFR1 |
| PLCD3 | PLC |