Fig. 3. Innervation patterns in animals expressing double-stranded RNA (dsRNA) constructs against Drosophila homologs of human genes at the 16p11.2 loci. Two representative NMJs are shown for larvae expressing dsRNAs against doc1 (A), CG10465 (B) and Klp68D (C). Note recurrent innervations induced by downregulation of KLP68D that re-route back to muscle 13 after their initial entry to muscle 12 (C), in contrast to WT-like morphology observed in (A) and (B). Scale bar, 20 µm.
