Fig. 10.

Release profiles of capsules containing 300 mg melt-extruded granules (30–20 mesh) with different theophylline loading levels; USP paddle method at 100 rpm; 900 mL medium at 37°C; 0–2 h in 0.1 N HCl; 2–6 h in 50 mM phosphate buffer pH 6.8; 610 h in 50 mM phosphate buffer pH 7.4. Triplicate samples (black triangle) 30% theophylline; (white square) 20% theophylline; (black diamond) 10% theophylline