Fig. 11.

Dissolution profiles of 5-ASA granules (20% drug and 80% Eudragit® FS, 30–20 mesh) prepared using different processes; USP paddle method at 100 rpm; 900 mL medium at 37°C; 0–2 h in 0.1 N HCl; 2–6 h in 50 mM phosphate buffer pH 6.8; 610 h in 50 mM phosphate buffer pH 7.4. Triplicate samples (black circle) dry granulation; (white circle) melt extrusion