Fig. 13.

Solubilization profiles of drug-free Eudragit® FS granules (20–30 mesh) prepared using different processes; USP paddle method at 100 rpm; 900 mL medium at 37°C; 0–2 h in 0.1 N HCl; 2–6 h in 50 mM phosphate buffer pH 6.8; 6–10 h in 50 mM phosphate buffer pH 7.4. Triplicate samples (white circle) dry granulation; (black diamond) melt extrusion