Fig. 6.

Dissolution profiles of 5-ASA capsules (10% drug loading in melt-extruded granules in 20–16 mesh) at initial time point and following 1 month storage at 40°C/75% RH and 60°C; USP paddle method at 100 rpm; 900 mL medium at 37°C; 0–2 h in 0.1 N HCl; 2–6 h in 50 mM phosphate buffer pH 6.8; 6–10 h in 50 mM phosphate buffer pH 7.4, triplicate samples. Initial time point (black diamond); 1 month at 40°C/75% RH (circle); 1 month at 60°C (black triangle)