Fig. 8.

Release profiles of the capsules containing melt-extruded sodium diclofenac granules (20–30 mesh and 10% drug loading in melt-extruded granules) containing different levels of sodium phosphate monobasic; USP paddle method at 100 rpm; 900 mL medium at 37°C; 0–2 h in 0.1 N HCl; 2–6 h in 50 mM phosphate buffer pH 6.8; 610 h in 50 mM phosphate buffer pH 7.4. Triplicate samples (black square) 0% NaH₂PO₄; (black circle) 5% NaH₂PO₄; (white square) 10% NaH₂PO₄