Fig. 9.

Release profiles of capsules containing 300 mg melt-extruded granules (30–20 mesh) with different 5-ASA loading levels in melt-extruded granules; USP paddle method at 100 rpm; 900 mL medium at 37°C; 0–2 h in 0.1 N HCl; 2–6 h in 50 mM phosphate buffer pH 6.8; 6–10 h in 50 mM phosphate buffer pH 7.4. Triplicate samples (black square) 10% 5-ASA; (white square) 20% 5-ASA; (black circle) 30% 5-ASA