Fig. 6.

Influence of triethyl citrate (TEC) concentration and pre-plasticization on drug release rate of hot-melt extruded tablets containing 25% w/w 5-aminosalicylic acid (ASA). black triangle Formulation A2, pre-plasticized 12% w/w TEC; black diamond formulation A1, no pre-plasticization 12% w/w TEC; and black square formulation B, pre-plasticized 23% w/w TEC. Dissolution medium consisted of 0.1 N hydrochloric acid (HCl) pH 1.2, from 0 to 2 h; 50 mM phosphate buffer pH 6.8, from 2 to 6 h; and pH 7.4, from 6 to 12 h at 37°C and 100 rpm, apparatus 2 (n = 3). Reprinted with permission from Bruce et al. 2005 (72)