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. 2015 Oct 13;17(1):120–132. doi: 10.1208/s12249-015-0417-7

Table VI.

MDSC Results of Processed Batches

Drug load (%) Polymer Process T g (°C) Melt endotherm (°C) Recrystallization exotherm
10 PVP K17 HME 132
20 PVP K17 HME 126
40 PVP K17 HME 120 195
10 HPMC E5 HME 114
20 HPMC E5 HME 98
40 HPMC E5 HME 90 209 +
10 PVP K17 KSD 133
20 PVP K17 KSD 125
40 PVP K17 KSD 113 196
10 PVP K30 KSD 152
20 PVP K30 KSD 142
40 PVP K30 KSD 123 203
10 PVP K90 KSD 166
20 PVP K90 KSD 141
40 PVP K90 KSD 131
10 HPMC E5 KSD 112
20 HPMC E5 KSD 100 204 +
40 HPMC E5 KSD 89 211 +
10 HPMC E15 KSD 115
20 HPMC E15 KSD 108 207 +
40 HPMC E15 KSD 90 214 +
10 HPMC E50 KSD 127
20 HPMC E50 KSD 110 207 +
40 HPMC E50 KSD 91 213 +

PVP polyvinylpyrrolidone, HPMC hydroxypropyl methylcellulose, HME hot-melt extrusion, KSD KinetiSol® Dispersing