Table VI.
Drug load (%) | Polymer | Process | T g (°C) | Melt endotherm (°C) | Recrystallization exotherm |
---|---|---|---|---|---|
10 | PVP K17 | HME | 132 | – | – |
20 | PVP K17 | HME | 126 | – | – |
40 | PVP K17 | HME | 120 | 195 | – |
10 | HPMC E5 | HME | 114 | – | – |
20 | HPMC E5 | HME | 98 | – | – |
40 | HPMC E5 | HME | 90 | 209 | + |
10 | PVP K17 | KSD | 133 | – | – |
20 | PVP K17 | KSD | 125 | – | – |
40 | PVP K17 | KSD | 113 | 196 | – |
10 | PVP K30 | KSD | 152 | – | – |
20 | PVP K30 | KSD | 142 | – | – |
40 | PVP K30 | KSD | 123 | 203 | – |
10 | PVP K90 | KSD | 166 | – | – |
20 | PVP K90 | KSD | 141 | – | – |
40 | PVP K90 | KSD | 131 | – | – |
10 | HPMC E5 | KSD | 112 | – | – |
20 | HPMC E5 | KSD | 100 | 204 | + |
40 | HPMC E5 | KSD | 89 | 211 | + |
10 | HPMC E15 | KSD | 115 | – | – |
20 | HPMC E15 | KSD | 108 | 207 | + |
40 | HPMC E15 | KSD | 90 | 214 | + |
10 | HPMC E50 | KSD | 127 | – | – |
20 | HPMC E50 | KSD | 110 | 207 | + |
40 | HPMC E50 | KSD | 91 | 213 | + |
PVP polyvinylpyrrolidone, HPMC hydroxypropyl methylcellulose, HME hot-melt extrusion, KSD KinetiSol® Dispersing