Table 1.
Potential problems reported with generic substitution of AEDs
| AEDs | Potential problems | References |
|---|---|---|
| Carbamazepine | Increased breakthrough seizures with generic substitution | Sachdeo and Belendiuk (1987), Welty et al. (1992), Koch and Allen (1987), Hartley et al. (1991), Berg et al. (2008), Hartley et al. (1990) |
| Failure of drug therapy with generic substitution | Meyer et al. (1992), Welty et al. (1992), Jain (1993) | |
| Toxicity and increased serum levels with generic substitution | Gilman et al. (1993), Jumao-as et al. (1989), Reunanen et al. (1992) | |
| Adverse effects with generics | Neuvonen (1985), Hartley et al. (1990), Olling et al. (1999), Garnett et al. (2005) | |
| Phenytoin | Increased breakthrough seizures with generic substitution | Yamada and Welty (Yamada and Welty 2011), Berg et al. (2008) |
| Toxicity and increased serum levels with generic substitution | Soryal and Richens (1992) | |
| Adverse effects with generics | Chen et al. (1982) | |
| Valproate | Increased breakthrough seizures with generic substitution | Berg et al. (2008) |
| Failure of drug therapy | Margolese et al. (2010), Sherr and Kelly (1998) | |
| Toxicity and increased serum levels with generic substitution | Levine et al. (2000) | |
| Adverse effects with generics | Margolese et al. (2010), Sherwood et al. (1998), Wassef et al. (2005), Zarate et al. (1999), Schwartz et al. (2000) | |
| Leviteracetam | Increased breakthrough seizures with generic substitution | Armstrong et al. (2010), Fitzgerald and Jacobson (2011), Chaluvadi et al. (2011) |
| Adverse effects with generics | (Chaluvadi et al. 2011) | |
| Topiramate | Increased breakthrough seizures with generic substitution | Duh et al. (2009b) |
| Adverse effects with generics | Pineyro-Lopez et al. (2009) | |
| Gabapentin | Increased breakthrough seizures with generic substitution | Berg et al. (2008) |
| Phenobarbital | Failure of drug therapy | Bankstahl et al. (2013) |
| Oxcarbazepine | Increased breakthrough seizures with generic substitution | Cook et al. (2009) |
| Lamotrigine | Increased breakthrough seizures with generic substitution | Makus and McCormick (2007), Nielsen et al. (2008) |
| Toxicity and increased serum levels with generic substitution | Srichaiya et al. (2008), Sabroe and Sabers (2008), Nielsen et al. (2008) | |
| Adverse effects with generics | Andermann et al. (2007), Makus and McCormick (2007) | |
| Primidone | Increased breakthrough seizures with generic substitution | Wyllie et al. (1987) |
| Zonisamide | Increased breakthrough seizures with generic substitution | Berg et al. (2008) |