Table 3.

Special categories of patients recommended for exclusion from the compulsory generic substitution (Lamy 1986; Krämer et al. 2007; Crawford et al. 2006)

Special categories	Examples
High risk patients	Extreme age groups, pregnant women, patients with multiple disorders being treated with several drugs, solitary individual, etc.
High risk diseases	Chronic diseases, diseases aggravated after the administration of drugs prescribed for co-morbid condition, etc.
High risk drugs	Narrow therapeutic index drugs, drugs requiring individualization of dose, drugs exhibiting severe drug–drug interactions, drugs with the complex therapeutic regimen, drugs initiating the prescribing cascade, etc.