Fig 1. Nox1*^/Y mice have improved survival and delayed weight loss following intranasal challenge with IAV.

B6 and Nox1*^/Y mice were challenged with 50 MID₅₀ IAV. Mortality is plotted in A as percentage of mice surviving over time. A significant difference (p<0.01) was observed between the B6 and Nox1*^/Y mortality curves by both the Log-rank test and the Gehan-Breslow-Wilcoxon Tests. Morbidity is plotted in B as percentage of weight on day of infection (day 0). Results represent mean values ± standard deviation from the mean (S.D.). Average percent original body weights were compared between B6 and Nox1*^/Y mice at individual days p.i. by a Student’s t test. Data compiled from two independent experiments; n = 15–16 mice per group (*, p < 0.05; **, p = 0.01).