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. 2016 Feb 24;11(2):e0150132. doi: 10.1371/journal.pone.0150132

Fig 5. Silencing integrin β3 expression diminishes migration and invasion-modulating properties of the HMF-Sdc1-derived ECM.

Fig 5

A) Quantitative assessment of migration directionality of MDA-MB-231 and MCF10DCIS.com cells within the ECMs produced by HMF-mock or HMF-Sdc1 cells treated with control or β3 siRNA using time-lapse microscopy. Different letters above columns indicate significant difference (p<0.001). B) Invasion of MDA-MB-231 and MCF10DCIS.com cells through ECMs produced by HMF-mock or HMF-Sdc1 cells treated with control or β3 siRNA. Different letters above columns indicate significant difference (at least p<0.05). Ctrl si, control siRNA; β3 si, β3 siRNA.