Table 1.

Chemokines and their receptors in the recruiment of bone marrow-derived fibroblast precusors or fibrocytes.

Chemokines/Receptors	Methods	Models	Effect on fibrosis	References
CCL21/CCR7	Anti-CCL21 antibody CCR7 knockout mice	UUO	40–50% reduction	Sakai et al., 2006
CXCL16	CXCL16 knockout mice	UUO	40–50% reduction	Chen et al., 2011
CCR2	CCR2 knockout mice, depletion of fibrocytes, BMT	UUO	20–30% reduction	Reich et al., 2013
CCR2	CCR2 knockout mice	UUO	30–40% reduction	Xia et al., 2013a
CXCL16	CXCL16 knockout mice	Angiotensin II infusion	40–50% reduction	Xia et al., 2013b
CXCR6	CXCR6 knockout mice, BMT	Angiotensin II infusion	40–50% reduction	Xia et al., 2014a
CXCR6	CXCR6 knockout mice, BMT	UUO, IRI	40–50% reduction	Xia et al., 2014b

BMT, bone marrow transplantation; IRI, ischemia-reperfusion injury; UUO, unilateral ureteral obstruction.