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. 2016 Feb 25;7:16. doi: 10.3389/fendo.2016.00016

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Copyright © 2016 Lischinsky, Skocic, Clairman and Rovet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sample regions showing significant correlations between CT and first-trimester maternal TSH. (A) Right lateral-view spatial map showing two nearby regions, indicating significant (p < 0.001) thickening (red) as first-trimester maternal TSH levels increased. (B) Correlation plots between individual CT values and first-trimester maternal TSH levels in two regions of right supramarginal gyrus. (C) Right lateral-view spatial map showing significant thickening (red) as first-trimester maternal TSH levels increased with M12 removed from FreeSurfer analysis. (D) Correlation plot between individual CT values and first-trimester maternal TSH levels in right supramarginal gyrus with M12 removed from FreeSurfer analysis. Note: correlations were retained when both outlying cases (M12 and M41) were removed from SPSS analyses shown in B (p = 0.006 and p = 0.01) and when M41 was removed from analysis shown in D (p = 0.002).