Table 2.

Cortical regions showing differences between HYPO (n = 20) and control (n = 24) groups^a.

Hemisphere	Region	Lobe	Brodmann area	Coordinatesb	Size (mm3)	Number of vertices	p-value
Thinning (HYPO < Control)c
Left	Insula	Frontal	13	−37, −15, 8	108.4	220	0.008
	Fusiform gyrus	Temporal	37	−32, −57, −11	93.8	146	0.026
Right	Frontomarginal sulcus	Frontal	10	25, 48, −4	90.8	137	0.029
	Inferior parietal gyrus	Parietal	39	53, −48, 28	97.6	210	0.015
	Precuneus gyrus	Parietal	31	15, −48, 35	86.8	265	0.04
Thickening (HYPO > Control)d
Left	Rostral middle frontal gyrus	Frontal	10	−32, 46, 13	105.6	155	0.007
	Superior frontal gyrus	Frontal	6	−19, −4, 58	160.0	315	0.0002
	Superior frontal gyrus	Frontal	6	−10, −7, 56	109.8	244	0.005
	Superior parietal gyrus	Parietal	7	−11, −64, 53	88.9	178	0.028
	Postcentral sulcus	Parietal	2	−54, −18, 31	90.2	187	0.025
Right	Temporal pole	Temporal	38	41, 11, −32	138.9	203	0.0008
	Inferior temporal gyrus	Temporal	37	48, −36, −17	115.7	232	0.003
	Pericalcarine sulcus	Occipital	17	19, −69, 13	91.6	162	0.03

^aExcluded from the original HYPO group were two children with unacceptable scans and two whose mothers’ TSH values were in the normal range throughout pregnancy.

^bTalairach coordinates (x, y, z) provide a three-dimensional atlas system that serves to map locations of specific brain structures; the x-coordinate indicates location in the right (positive)/left (negative) direction, y indicates anterior (positive)/posterior (negative) direction, and z signifies superior (positive)/interior (negative) direction.

^cShown as red tones in Figure 1 to denote Control > HYPO, as per heat bars.

^dShown as blue tones in Figure 1 to denote Control < HYPO.