Table 3.

Regions showing cortical thickness differences between Severe (n = 11) and Mild (n = 10)^a HYPO subgroups^b.

Hemisphere	Region	Lobe	Coordinatesc	Size (mm2)	Number of vertices	p-value
Thinning (Severe < Mild)d
Left	Medial orbitofrontal sulcus	Frontal	−7, 25, −11	108.88	223	0.0002
	Fusiform gyrus	Temporal	−40, −70, −11	53.80	80	0.03
Right	Orbital gyrus	Frontal	24, 10, −15	54.22	145	0.03
Thickening (Severe > Mild)e
Left	Precentral gyrus	Frontal	−21, −15, 65	56.06	150	0.025
	Precuneus gyrus	Parietal	−8, −54, 38	118.68	213	0.0002
	Superior occipital sulcus	Occipital	−22, −74, 34	74.79	110	0.002
Right	Precentral gyrus	Frontal	44, 2, 37	51.08	81	0.05
	Lateral orbital sulcus	Frontal	19, 22, −17	54.47	100	0.03

^aSample size includes the two children whose mothers had normal-range TSH values throughout pregnancy but excludes the one child whose mothers’ specific TH value information was missing.

^bDefined as TSH above or below 8.8 mU/l in first or second trimesters. Ranges: Mild = 0.1–8.4; Severe = 8.8–38.5 mU/l.

^cSee description of Talairach coordinates in Table 2.

^dShown as red tones in Figure 2 to denote Mild > Severe.

^eShown as blue tones in Figure 2 to denote Mild < Severe.