Table 1.
Demographic and clinical characteristics of patients with pGBM.
| Characteristics | tMSLCs (+) (N = 48) | tMSLCs (−) (N = 34) | P value |
|---|---|---|---|
| Age (years) | 0.683 | ||
| Median | 57.5 | 61.0 | |
| Range | 28~85 | 24~80 | |
| Age, no. (%) | 0.899 | ||
| <50 years, no. (%) | 9 (19) | 6 (18) | |
| ≥50 years, no. (%) | 39 (81) | 28 (82) | |
| Gender | 0.110 | ||
| Male, no. (%) | 33 (69) | 17 (50) | |
| Female, no. (%) | 15 (31) | 17 (50) | |
| Median survival (months) | 15.0 | 29.5 | 0.014 |
| 95% CI | 9.6~20.4 | 11.9~47.1 | |
| Pathological diagnosis | pGBM | pGBM | |
| Treatment | OP/Stupp | OP/Stupp | |
| Extent of operation (patients) | 0.471 | ||
| Gross total resection (≥100%) | 29 (60) | 19 (56) | |
| Subtotal resection (90% ≤, <100%) | 18 (38) | 12 (35) | |
| Partial resection (<90%) | 1 (2) | 3 (9) | |
| Molecular markers | |||
| IDH1 | 0.642 | ||
| Wild type, no. (%) | 39 (91) | 26 (96) | |
| Mutation, no. (%) | 4 (9) | 1 (4) | |
| Missing data, no. (%) | 5 (10) | 7 (21) | |
| 1p19q | 0.341 | ||
| No codeletion, no. (%) | 37 (80) | 30 (91) | |
| Median survival (months) | 15.0 | 29.5 | 0.011 |
| 95% CI | 8.9~21.1 | 9.1~50.0 | |
| Codeletion, no. (%) | 9 (20) | 3 (9) | |
| Median survival (months) | 12.9 | 9.3 | 0.886 |
| 95% CI | 0.8~25.0 | 1.6~17.0 | |
| Missing data, no. (%) | 2 (4) | 1 (3) | |
| MGMT promoter | 0.653 | ||
| Wild type, no. (%) | 27 (59) | 18 (53) | |
| Median survival (months) | 15.0 | NA | 0.122 |
| 95% CI | 8.8~21.2 | NA | |
| Methylated, no. (%) | 19 (41) | 16 (47) | |
| Median survival (months) | 18.6 | 34.1 | 0.164 |
| 95% CI | 6.2~31.0 | 13.6~54.6 | |
| Missing data, no. (%) | 2 (4) | 0 (0) | |
| p53 | 0.522 | ||
| IHC negative (<50%), no. (%) | 23 (77) | 13 (65) | |
| Median survival (months) | 13.7 | NA | 0.324 |
| 95% CI | 9.8~17.6 | NA | |
| IHC positive (≥50%), no. (%) | 7 (23) | 7 (35) | |
| Median survival (months) | 18.6 | NA | 0.704 |
| 95% CI | 9.9~27.3 | NA | |
| IHC mean ± S.D. | 28.4 ± 27.0 | 33.9 ± 28.8 | 0.492 |
| Range (%) | 1.5~85 | 2.5~90 | |
| Missing data, no. (%) | 18 (38) | 14 (41) | |
| EGFR | |||
| IHC mean ± S.D. | 1.9 ± 1.1 | 2.3 ± 0.9 | 0.161 |
| Range | 0~3 | 0~3 | |
| Missing data, no. (%) | 6 (13) | 7 (21) | |
| Ki 67 | 0.739 | ||
| IHC negative (<10%), no. (%) | 5 (11) | 3 (9) | |
| IHC positive (≥10%), no. (%) | 40 (89) | 31 (91) | |
| IHC % mean ± S.D. | 22.6 ± 14.1 | 30.1 ± 20.2 | 0.057 |
| Range (%) | 2~60 | 3~80 | |
| Missing data, no. (%) | 3 (6) | 0 (0) |
S.D.: standard deviation; IDH: isocitrate dehydrogenase; LOH: loss of heterozygosity; OP/Stupp: operation followed by Stupp's regimen; MGMT: O-6-methylguanine-DNA methyltransferase; EGFR: epidermal growth factor receptor; NA: not available.