Table 2.
Cox proportional hazard regression model of factors prognostic of overall survival in patients with pGBM.
| Characteristics | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | |
| Isolation of tMSLCs | 2.4 | 1.2~5.1 | 0.017 | 2.5 | 1.1~5.6 | 0.021 |
| Age ≥ 50 years | 1.3 | 0.5~3.1 | 0.587 | |||
| Extent of resection | 0.7 | 0.4~1.1 | 0.151 | 0.5 | 0.2~0.8 | 0.011 |
| IDH1 mutation | 1.6 | 0.4~6.7 | 0.551 | |||
| LOH 1p19q | 1.3 | 0.6~3.0 | 0.532 | 1.1 | 0.4~2.6 | 0.869 |
| MGMT methylation | 0.8 | 0.4~1.6 | 0.522 | 0.9 | 0.4~1.9 | 0.792 |
| p53 ≥ 50% | 0.7 | 0.2~1.8 | 0.418 | |||
| EGFR | 1.1 | 0.7~1.5 | 0.782 | |||
| Ki 67 index ≥ 10% | 3.3 | 0.5~24.7 | 0.235 | 5.4 | 0.7~42.0 | 0.107 |
tMSLCs: tumor mesenchymal stem-like cells; IDH: isocitrate dehydrogenase; LOH: loss of heterozygosity; MGMT: O-6-methylguanine-DNA methyltransferase; EGFR: epidermal growth factor receptor; OR: odds ratio; CI: confidence interval.