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. Author manuscript; available in PMC: 2016 Feb 25.
Published in final edited form as: Sci Signal. 2015 Jan 27;8(361):ra11. doi: 10.1126/scisignal.2005548

Fig. 5. Regulation of hepatic TNFR1 shedding through the iNOS-cGMP pathway modulates inflammatory responses and liver injury during sepsis.

Fig. 5

(A to F) WT mice were subjected to CLP and then were immediately treated subcutaneously with saline, 1400W (5 mg/kg), 8-CPT-cGMP (5 mg/kg), both 1400W and 8-CPT-cGMP, or ODQ (20 mg/kg). Eight hours after CLP, plasma concentrations of (A) IL-6, (B) TNF, (C) KC, (D) MIP-1α, (E) HMGB1, and (F) ALT were measured by ELISA. Data are means ± SD from 8 to 10 mice per group from two experiments. *P < 0.05 by one-way ANOVA. (G to I) WT mice were subjected to CLP and then were immediately treated subcutaneously with saline or sildenafil (50 mg/kg). Eight hours after CLP, the concentrations of (G) cGMP in liver homogenates and of (H) TNFR1 and (I) IL-6 in the plasma were determined. Data are means ± SD from six mice per group. *P < 0.05 by one-way ANOVA.