Table 1. Substitution rate of LASV in M. natalensis and age of main clades.
Model | Molecular clock/codon partition | AICM value | Substitution rate, median (95% HPD) [mutation x position–1 year–1] | Root age, median (95% HPD) [years] | Faranah II cluster age, median (95% HPD) [years] | Faranah III cluster age, median (95% HPD) [years] |
---|---|---|---|---|---|---|
#1 | Strict/no partition | 11836 | 8.93 (6.70–11.35) × 10–4 | 83.5 (60.1–113.2) | 55.3 (41.4–73.3) | 44.7 (34.3–57.4) |
#2 | Strict/codons 1, 2, 3 | 11523 | 8.91 (6.78–11.25) × 10–4 | 84.9 (60.7–114.0) | 56.0 (41.1–73.8) | 45.5 (35.3–58.0) |
#3 | Relaxed lognormal/no partition | 11911 | 8.89 (6.67–11.43) × 10–4 | 84.7 (57.4–119.0) | 56.1 (39.3–76.2) | 45.7 (34.5–59.4) |
#4 | Relaxed lognormal/codons 1, 2, 3 | 11535 | 8.89 (6.42–11.31) × 10–4 | 86.2 (59.4–126.3) | 56.4 (39.2–77.3) | 46.0 (34.0–60.0) |
Analysis was performed using GTR + gamma and constant population size.
Abbreviations: 95% HPD, Highest Posterior Density interval contains 95% of the posterior probability distribution; AICM, model evaluation using Akaike’s information criterion through Markov chain Monte Carlo. Lower values indicate a better fit to the data.