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(a–d) Levels of hippocampal TBS-soluble human Aβ40 (a) and Aβ42 (c) did not differ between 11-month old C/C and HF/C Tg2576 mice. However, HF/C mice had significantly higher levels of guanidine-soluble Aβ40 (b) and Aβ42 (d) compared to C/C animals. (e) The plasma ratio of Aβ42:Aβ40 was also higher in HF/C vs. C/C mice. *p < 0.05.
