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. 2015 Aug 27;16(10):1358–1377. doi: 10.15252/embr.201540750

Figure 7. miR‐9‐5p regulates TGFBR2 and NOX4 expression and inhibits Smad2 phosphorylation in mouse lungs.

Figure 7

  1. qRT–PCR analysis of TGFBR2 expression in lungs from mice administered lenti‐SC (control) or lenti‐miR‐9 (1 × 106 i.f.u.) (n = 4 mice per group).
  2. qRT–PCR analysis of NOX4 expression in lungs from mice given lenti‐SC (control) or lenti‐miR‐9 (1 × 106 i.f.u. per mouse) for 4 days followed by orotracheal bleomycin administration (1.5 U/kg body weight in 40 μl saline) or saline for 14 days (n = 4 mice per group).
  3. Microphotographs of TGFBR2 and pSmad2 expression in mouse lung samples described in (B) (n = 4 mice per group). Scale bars: 100 μm.
Data information: Bar graphs show mean ± SEM; two‐tailed Mann–Whitney U‐test; *P ˂ 0.05 compared to saline‐treated mice administered lenti‐SC and # P ˂ 0.05 compared to bleomycin‐treated mice administered lenti‐SC.