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. 2016 Feb 25;6:21972. doi: 10.1038/srep21972

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Copyright © 2016, Macmillan Publishers Limited

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JC-1 fluorescent dye in the mitochondrialmatrix produces red fluorescence. If the mitochondrial membrane potential (ΔΨ_m) declines, JC-1 becomes a monomer in the matrix and produces green fluorescence. (A), Representative pictures of JC-1 fluorescence (indicating mitochondrial depolarization) detected by laser confocal microscopy. Scale bar, 20 μm. (B), Quantitative analysis of fluorescence intensity in the mitochondria of cardiomyocytes shown in A. RhCEACAM1 decreased the ΔΨ_m of hypoxic cardiomyocytes (n = 4 in each group). ^*P < 0.01 vs. normoxia and ^#P < 0.05 vs. hypoxia.