Table 1.
FGE form does not correlate with conversion yield
| Transient Ab 1, CH-CT | Transient Ab 2, Hinge | Stable Ab 1, CH-CT | Stable Ab 2, CH-CT | Stable Ab 2, Hinge | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Clone | FGE forma | FGE levels | Titers (mg/L) | Conversion | Titers (mg/L) | Conversion | Titers (mg/L) | Conversion | Titers (mg/L) | Conversion | Titers (mg/L) | Conversion |
| 395-12 | WT | Low | 11.8 | 96 % | 10.5 | 81 % | ND | ND | 2.1 | 99 % | 1.6 | 99 % |
| 395-12 | WT | Low | 3.7 | 90 % | 6.6 | 69 % | ND | ND | 1.6 | 98 % | ND | ND |
| 408-102 | ∆Fur + KDEL | High | 11.5 | 95 % | 9.9 | 81 % | ND | ND | 1.1 | 98 % | 1.2 | 90 % |
| 409-107 | ∆Fur + KDEL | Low | 1.4 | 83 % | 6.8 | 69 % | 2 | 97 % | 1.1 | 97 % | ND | ND |
| 407-118 | +KDEL | High | 11.8 | 97 % | ND | ND | 4.7 | 97 % | 0.9 | 98 % | 1.3 | 99 % |
| 406-127 | ∆Fur | Med | 1.9 | 80 % | 7.4 | 54 % | 7.8 | 92 % | 1.5 | 94 % | ND | ND |
| 409-35 | ∆Fur + KDEL | Med | ND | ND | 6.5 | 68 % | 1.7 | 92 % | 2 | 98 % | ND | ND |
a∆Fur, deleted furin cleavage site