Table 3.
Micro-CT analysis and bone turnover
| No BML (n = 12) | BML (1 + 2) (n = 44) | P value | |
|---|---|---|---|
| Micro-CT - subchondral plate | |||
| Pl.Th, mma | 0.44 ± 0.10 | 0.95 ± 0.29 | 0.001 |
| Surface cl.poresb | 49.5 (23, 83.7) | 103.7 (60, 203) | 0.007 |
| Micro-CT - subchondral trabeculae | |||
| BV/TV, %a | 12.06 ± 3.5 | 16.7 ± 5.1 | 0.02 |
| Tb.N, number/mma | 0.9 ± 0.2 | 1.2 ± 0.3 | 0.04 |
| Tb.Sp, mmb | 0.9 (0.9, 1) | 1.2 (1, 1.5) | 0.06 |
| Tb.Th, mmb | 0.13 (0.11, 0.15) | 0.14 (0.12, 0.16) | 0.2 |
| Tb.Pfa | -2.2 ± 3.7 | -9.3 ± 7.8 | 0.02 |
| SMIa | 1.32 ± 0.4 | 0.62 ± 0.8 | 0.02 |
| DAb | 1.5 (1.4, 1.6) | 1.6 (1.5, 1.8) | 0.5 |
| Bone remodeling - subchondral plate | |||
| O.Th, μma | 36 ± 8.9 | 43 ± 10.9 | 0.03 |
| OS/BS, %b | 2.5 (1.1, 3.6) | 5.1 (3.6, 7.2) | 0.0001 |
| OS/BV, mm2/mm3b | 1.9 (0.8, 2.8) | 2 (1.5, 3.6) | 0.3 |
| OS/TV, mm2/mm3a | 0.4 ± 0.2 | 0.8 ± 0.4 | 0.004 |
| OV/BV, %b | 7.1 (3.4, 8.8) | 9.4 (6.1, 15) | 0.08 |
| OV/TV, %b | 1.6 (0.7, 2.1) | 3.5 (2, 5.6 | 0.001 |
| ES/BS, %b | 0.03 (0, 0.1) | 0.09 (0.01, 0.17) | 0.1 |
| ES/BV, mm2/mm3b | 0.02 (0, 0.06) | 0.03 (0.007, 0.07) | 0.5 |
| ES/TV, mm2/mm3b | 0.004 (0, 0.01) | 0.01 (0.002, 0.02) | 0.1 |
| Bone remodeling - subchondral trabeculae | |||
| O.Th, μmb | 24.7 (22.4, 32.2) | 38.1 (27.6, 46.3) | 0.005 |
| OS/BS (%)b | 3.4 (1.9, 3.9) | 3 (1.4, 5.8) | 0.6 |
| OS/BV, mm2/mm3b | 1.9 (1.1, 2.9) | 2.2 (1.4, 3.5) | 0.3 |
| OS/TV, mm2/mm3b | 0.4 (0.3, 0.5) | 0.7 (0.4, 1.1) | 0.04 |
| OV/BV, %b | 3.6 (2.3, 5.5) | 4.7 (2.0, 7.3) | 0.04 |
| OV/TV, %b | 1.2 (0.8, 1.7) | 2 (1.2, 5.4) | 0.008 |
| ES/BS, %b | 0.2 (0.1, 0.5) | 0.1 (0.09, 0.2) | 0.02 |
| ES/BV, mm2/mm3b | 0.1 (0.04, 0.1) | 0.07 (0.05, 0.1) | 0.8 |
| ES/TV, mm2/mm3b | 0.02 (0.01, 0.03) | 0.02 (0.01, 0.04) | 0.7 |
aValues presented with mean ± standard deviation. bValues presented with median (25th, 75th percentiles). P values are for difference between the group with no bone marrow lesions (no BML) and the group with BML (BML 1 + BML 2). cl.pores closed pores, Micro-CT micro computed tomography, BV bone volume, TV tissue volume, Tb.N trabecular number, Tb.Sp trabecular separation, SMI structural model index, Tb.Th trabecular thickness, O.Th osteoid thickness, OS osteoid surface, BS bone surface, ES erosion surface, OV osteoid volume, Pl.Th Plate thickness, Tb.Pf trabecular patern factor, DA degree of anisotropy